1. Combined effect of low-frequency high‑intensity ultrasound and streptokinase on the efficiency of thrombi destruction

I. Adzerikho1, A. Bubulis2, V. Jurėnas3, V. Minchenya4, V. Veikutis5, A. Vilkauskas6, A. Puodžiukynas7

1State Higher Educational Establishment “Belarusian Medical Academy of Post-Graduate Education”,
P. Brovki Str. 3, 220013 Minsk, Republic of Belarus

2, 3, 6Kaunas University of Technology, Donelaičio 73, LT-44029 Kaunas, Lithuania

4Belarusian National Technical University, 65 Independence Ave., 220027 Minsk, Republic of Belarus

5, 7Lithuanian University of Health Sciences, Institute of Cardiology, Sukilėlių 17, Kaunas, Lithuania

2Corresponding author

E-mail: 2algimantas.bubulis@ktu.lt, 3vytautas.jurenas@ktu.lt, 4vlad_minch@mail.ru

(Received 22 October 2012; accepted 4 March 2013)

Abstract. Results of numerous experimental studies indicate that low-intensity ultrasound (US) intensifies the drug induced fibrinolysis. However, exits opinion, what high-intensity ultrasound could be not recommending for use in combination with thrombolytic agents due to the transience of exposure of thrombus to ultrasound and relatively low speed of the enzymatic process. We also hypothesise that high-intensity low-frequency US can accelerate the drug induced fibrinolysis. During in vitro studies, we showed that the administration of streptokinase (SK) prevents the formation of particle conglomerates resulting due to destruction of fibrin clots by using low-frequency high-intensity US. In addition, it was established that in conditions of the combined effect of streptokinase and high-intensity US, the process of acoustic-mechanical destruction of thrombus is prevailing, and the fibrinolytic effect of streptokinase is generally witnessed after the termination of US and manifests itself in enzymatic lysis of both resultant particles and residual clot mass. In this study we verified the effect of low-frequency high-intensity ultrasound on the dynamics and efficiency of fibrinolysis induced by streptokinase on various structure thrombi model, characteristic features of the fibrin clot network structure occurring during the combined effect of ultrasound and streptokinase.

Keywords: low-frequency, ultrasound, piezoelectric transducer, drug induced fibrinolysis, combined thrombolytic therapy.

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Cite this article

Adzerikho I., Bubulis A., Jurėnas V., Minchenya V., Veikutis V., Vilkauskas A., Puodžiukynas A. Combined effect of low-frequency high-intensity ultrasound and streptokinase on the efficiency of thrombi destruction. Journal of Measurements in Engineering, Vol. 1, Issue 1, 2013, p. 1‑7.

 

Journal of Measurements in Engineering. March 2013, Volume 1, Issue 1
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