28. Tissue oxygenation through combined laser and ultrasound action

M. M. Asimov1, R. M. Asimov2, A. N. Rubinov3

1, 3Institute of Physics National Academy of Sciences of Belarus, Minsk, Belarus

2Sensotronica Ltd., Belarus High Technologies Park, Minsk, Belarus

1Corresponding author

E-mail: 1m.asimov@dragon.bas-net.by, 2roustam.asimov@sensotronica.com, 3rubinov@dragon.bas-net.by

(Received 5 December 2012; accepted 15 September 2013)

Abstract. The results in vivo investigation biophotonics of laser‑induced photodissociation of oxyhemoglobin in cutaneous blood vessels and its role in biomedical processes are presented. It is shown that in order to make the methods of phototherapy as well as laser therapy really efficient one has to control the oxygen concentration in tissue keeping it at the necessary level. Perspectives of combined laser‑ultrasound application for improving oxygen diffusion are discussed.

Keywords: hemoglobin, oxyhemoglobin, tissue oxygenation, ultrasound, phototherapy, photodissociation.


[1]        Takas S., Stojanovich S. Diagnostic and biostimulating lasers. Med. Pregl., Vol. 51, Issue 5‑6, 1998, p. 245‑249.

[2]        Baxter G. D. Therapeutic lasers: Theory and Practice. Edinburgh, New-York, 1994.

[3]        Tuner J., Hode L. Laser Therapy: Clinical practice and scientific background. Prima Books AB, 2002.

[4]        Mostovnikov V. A., Mostovnikova G. R., Plavski V. Yu, Plavskaya L. G. Biophysical principles of regulatory action of low-intensity laser irradiation. Proc. SPIE., Vol. 2728, 1996, p. 50‑62.

[5]        Asimov M. M., Asimov R. M., Rubinov A. N. Investigation of the efficiency of laser action on hemoglobin and oxyhemoglobin in the skin blood vessels. Proc. SPIE., Vol. 3254, 1998, p. 407‑412.

[6]        Asimov M. M., Asimov R. M., Rubinov A. N. Action spectra of laser radiation on hemoglobin of skin blood vessels. Journal of Applied Spectroscopy, Vol. 65, Issue 6, 1998. p. 877‑880.

[7]        Asimov M., Asimov R., Mirshahi M., Gizbrebrecht A. Effect of laser induced photodissociation of oxyhemoglobin on biomedical processes. 11th International School on Quantum Electronics: Laser physics and Applications, Proc. SPIE., Vol. 4397, 2001, p. 390‑394.

[8]        Asimov M. M. Laser-induced Photodissociation of Hemoglobin Complexes with Gas Ligands and its Biomedical Applications. Proc. of LTL Plovdive 2005, IV International Symposium Laser Technologies and Lasers, Plovdive, Bulgaria, 2005, p. 3‑11.

[9]        Saffran Wilma A., Quentine H. Gibson Photodissociation of Ligands from Hem and Hem Proteins: Effect of Temperature and Organic Phosphate. Journal of Biol. Chem., Vol. 252, 1977, p. 7955‑7958.

[10]     Asimov M. M., Korolevich A. N., Konstantinova E. E. Investigation of the kinetics of tissue oxygenation under the effect of low intensity laser radiation. Journal of Appl. Spectr., Vol. 74, 2007, p. 120‑125.

[11]     Mortimer A. J., Trollope B. J., Villeneuve E. J., Roy O. Z. Ultrasound-enhanced diffusion through isolated frog skin. Ultrasonics, Vol. 26, Issue 6, 1988, p. 348‑351.

Cite this article

Asimov M. M., Asimov R. M., Rubinov A. N. Tissue oxygenation through combined laser and ultrasound action. Journal of Measurements in Engineering, Vol. 1, Issue 4, 2013, p. 178‑182.


Journal of Measurements in Engineering. December 2013, Volume 1, Issue 4
Vibroengineering. ISSN Print 2335-2124, ISSN Online 2424-4635, Kaunas, Lithuania